Vaccine boosts your immune system

Researchers at the Biotech Research and Innovation Centre (BRIC) at the University of Copenhagen have discovered a protein normally found in the body that can act to prevent chronic tissue inflammation. When administered in the form of a therapeutic vaccine it is able to effectively prevent and treat a number of different inflammatory disease models for multiple sclerosis (MS), rheumatoid arthritis (RA), skin hypersensitivity and allergic asthma (AA).
 
The results of this study have just been published by the prestigious Journal of Clinical Investigation in the article entitled “Endogenous collagen peptide activation of CD1d-restricted NKT cells ameliorates multiple tissue-specific inflammation in mice”.

Translational collaboration :
The study was led by Principal Investigator Shohreh Issazadeh-Navikas, group leader for Neuroinflammation Unit at BRIC, and was the result of a translational collaboration involving researchers in Denmark, Sweden and Germany. The article culminates a decade’s long search for ways to combat inflammation and inflammatory diseases.

“The implications of the findings are large as they shed light on an important way that the body combats inflammation and autoimmunity. Moreover, they establish a therapeutic approach for using the newly discovered protein as a treatment for multiple conditions,” says Shohreh Issazadeh-Navikas.

Many inflammatory and autoimmune diseases are chronic and affect a large majority of people. Moreover, there is an inflammatory component to many common diseases, such as Alzheimer’s, Parkinson’s, RA, AA, MS, type II diabetes and cancers.

Data offer new perspective :
This highly significant and novel finding offers a new perspective on the ways in which the body combats inflammation in both health and disease. In addition, the researchers identified the activation requirements and signaling pathway through which they exert their function.

Professor Issazadeh-Navikas highlights, “Our data offer a novel perspective on the physiological role of these cells in maintenance of tissue homeostasis and reduction of inflammation.”

The findings significantly advance the fields of autoimmunity, antigen presentation, and NKT cells. They provide mechanistic insight into the biology of these cells and their roles in disease and point the way to therapies to treat many of the common conditions of mankind.

For further information, please contact:

BRIC
Professor Shohreh Issazadeh-Navikas, PhD
Group leader for Neuroinflammation Unit
Tel.: +45 35 32 56 49
Mobile: +46 760 220 649
E-mail: shohreh.issazadeh@bric.ku.dk

Katrine Sonne-Hansen
Research coordinator
Mobile: +45 25 85 47 42
E-mail: Katrine.Sonne@bric.ku.dk

Or visit: www.ku.dk